Testicular Carcinoid

Figure 1: Large heterogeneous mass in the LT testicle

Figure 2: LT testicular mass has extensive vascularity on color doppler images.  Also has a cystic area.  This was a carcinoid tumor of the LT testicle mixed with teratoma.

Carcinoid tumor of the testis can occur as a primary neoplasm or as metastases. This tumor accounts for less than 1% of all testicular neoplasms, with 1.1%–3.1% of cases associated with carcinoid syndrome. They are most common in individuals ranging in age from 40 to 60 years. 25% of primary testicular carcinoid tumors are mixed with teratoma, these have a better prognosis. Orchiectomy is generally curative. Long-term follow-up is recommended.


Primary Carcinoid Tumor of the Testis Found at the Time of Elective Sterilization.  JOHN C. THOMAS AND J. STEPHEN JONES. Journal of Andrology, Vol. 25, No. 3, May/June 2004

St Lukes Update

The Radiology Residency at St Lukes is progressing nicely.  The reading room renovations are nearly complete and new ergonomic workstation tables have been delivered and are being set up.  Thanks to everyone involved in this transition it has gone very well.  I will post images of the new reading area when it is set up.

Constrictive pericarditis (CP) is a reduction in the elasticity, or stiffening, of the pericardium. This results in impaired filling of the heart with blood. Symptoms include, exercise intolerance, liver failure, dyspnea, and renal failure, Causes include: Viral infection, Tuberculosis (15% of cases). Surgery. Irradiation. Hemodialysis, Neoplasia with pericardial infiltration,. Bacterial, fungal, or parasitic infections. Inflammation after myocardial infarction (Dressler syndrome). Asbestosis . Autoimmune diseases. Imaging findings, such as calcifications and thickening of the pericardium, may be present, but the most reliable and most important findings are related to the filling pattern of the heart. Patients respond to a complete surgical pericardiectomy.

Metachromatic Leukodystrophy

SEPTEMBER IS LEUKODYSTROPHY MONTH

Metachromatic leukodystrophy is an autosomal recessive disorder caused by a deficiency of the lysosomal enzyme arylsulfatase A,  necessary for the normal hydrolysis of sulfatides (cerebroside 3-sulfate). Sulfatides are a component of the myelin. With metachromatic leukodystrophy, sulfatides accumulate within glial cells and neurons in the white matter of the brain, destroying normal myelin. It is diagnosed biochemically on the basis of an abnormally low level of arylsulfatase A in peripheral blood leukocytes and in the urine.   

There are three types of metachromatic leukodystrophy based on patient age at presentation: late infantile, juvenile, and adult. The most common type is late infantile metachromatic leukodystrophy.  Our patient presented as an adult. Adult metachromatic leukodystrophy can appear in adults of any age. The first symptoms are often changes in personality. Adult metachromatic leukodystrophy  is often misdiagnosed as other disorders such as schizophrenia or depression. As the disease progresses,  memory impairment, speech, and movement control slowly get worse . People with adult metachromatic leukodystrophy may sometimes live 10 to 30 years or more after onset.

MRI findings are symmetric, confluent high signal intensity on FLAIR / T2-weighted images in the periventricular white matter and centrum semiovale. A posterior predominance of white matter abnormalities has been noted.  Subcortical U fibers can be involved later in demyelination. Other sites of involvement were the genu and splenium of the corpus callosum, the posterior limbs of the internal capsule, the descending pyramidal tracts, the claustrum, and the cerebral white matter. Diffuse brain atrophy may result. No enhancement  is seen.

The only treatment that may affect the progression of metachromatic leukodystrophy  is a bone marrow or cord blood transplant. Transplant cells can make the arylsulfatase A . Recombinant human arylsulfatase A is being evaluated in Europe for enzyme replaement.

CheonJE, Kim IO, Hwang YS, et al. Leukodystrophy in children: a pictorial review of MR imaging features. RadioGraphics 2002; 22: 461–476.

Case Conference For 8.27.09

Case Conference for 8.27.09

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MR Ductography at 3T

This is an MR ductogram done at 3T with a fluid sensitive heavy T2 sequence. The patient had extensive bilateral ductal ectasia / dilatation due to long term antipsychotic meds.

Great News

In addition to St Lukes as a new teaching site for our residency program, the largest hospital in town and the largest group in Toledo are now teaching affiliates of UT's radiology residency progrm. TRA and The Toledo Hospital are going to host rotations in IR and Nucs. This adds tremendous experties and a large voulme of interesting cases to the training program. Dr Tom Win will be the site director for TTH/TRA.