Ulcerative Colitis

Fig 1. coronal CT abdomen and pelvis. Mildly distended colon with loss of haustral markings.






Fig 2. Coronal 3d. featureless, lead pipe colon

Ulcerative colitis is a type of inflammatory bowel disease. It involves the large intestine with characteristic ulcers. Symptoms include bleeding and diarrhea. Like Crohns, Ulcerative colitis is an intermittent disease, with periods of active disease and periods that are asymptomatic.

Ulcerative colitis occurs in less than 0.1% of the population. The disease is more prevalent in northern countries. Ulcerative colitis has no definIte cause. These appears to be a genetic component. Treatment is with anti-inflammatory drugs, immunosuppression, and biological therapy targeting specific components of the immune response. Colectomy (partial or total removal of the large bowel through surgery) is occasionally necessary, and is considered to be a cure for the disease.

In patients with long standing disease, a lead-pipe colon can develop. There is hypertrophy of the muscularis mucosa. The thickened muscle layer gives the colon a narrowed ahaustral form. Strictures may also narrow the lumen.


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